https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Altered expression of microRNA in the airway wall in chronic asthma: miR-126 as a potential therapeutic target https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:11837 Wed 11 Apr 2018 16:30:22 AEST ]]> Development of asthmatic inflammation in mice following early-life exposure to ambient environmental particulates and chronic allergen challenge https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:14146 Wed 11 Apr 2018 15:12:12 AEST ]]> Are mouse models of asthma appropriate for investigating the pathogenesis of airway hyper-responsiveness? https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:15981 Wed 11 Apr 2018 14:59:45 AEST ]]> Epigenetic changes associated with disease progression in a mouse model of childhood allergic asthma https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:15241 + T cells. We found that a limited number of microRNAs exhibited marked up- or downregulation following early-life infection and sensitisation, for many of which the levels of expression were further changed following chronic challenge with the sensitizing antigen. Targets of these microRNAs included genes involved in immune or inflammatory responses (e.g. Gata3, Kitl) and in tissue remodelling (e.g. Igf1, Tgfbr1), as well as genes for various transcription factors and signalling proteins. In pulmonary CD4+ T cells, there was significant demethylation at promoter sites for interleukin-4 and interferon-γ, the latter increasing following chronic challenge. We conclude that, in this model, progression to an asthmatic phenotype is linked to epigenetic regulation of genes associated with inflammation and structural remodelling, and with T-cell commitment to a Th2 immunological response. Epigenetic changes associated with this pattern of gene activation might play a role in the development of childhood asthma.]]> Wed 11 Apr 2018 14:44:33 AEST ]]> Early-life viral infection and allergen exposure interact to induce an asthmatic phenotype in mice https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:10124 Wed 11 Apr 2018 10:19:59 AEST ]]> Mouse models of acute exacerbations of allergic asthma https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:24599 Thu 03 Feb 2022 12:22:09 AEDT ]]> Pneumococcal conjugate vaccine-induced regulatory T cells suppress the development of allergic airways disease https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:9358 Sat 24 Mar 2018 08:36:33 AEDT ]]> Epigenetic changes in childhood asthma (commentary) https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:8198 Sat 24 Mar 2018 08:36:19 AEDT ]]> Ym1/2 promotes Th2 cytokine expression by inhibiting 12/15(S)-lipoxygenase: identification of a novel pathway for regulating allergic inflammation https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:7312 Sat 24 Mar 2018 08:34:00 AEDT ]]> Pathogenesis of steroid-resistant airway hyperresponsiveness: interaction between IFN-γ and TLR4/MyD88 pathways https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:7244 Sat 24 Mar 2018 08:33:46 AEDT ]]> Emerging roles of pulmonary macrophages in driving the development of severe asthma https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:15983 50% of asthma-related healthcare costs. New investigations into the pathogenesis of glucocorticoid resistance in severe asthma indicate that pulmonary macrophages may play central roles in promoting airway inflammation, particularly in asthma that is resistant to steroid therapy. Importantly, factors that are linked to the activation of pulmonary macrophages may contribute to glucocorticoid resistance and severe asthma. Here, we review recent advances in understanding the roles of pulmonary macrophages in the mechanisms of glucocorticoid resistance and the pathogenesis of severe asthma. We discuss the role of macrophage phenotype, infection, IFN-γ, LPS, associated signaling pathways, TNF-α, MIF, and other macrophage-associated factors. Understanding the pathogenesis of steroid-resistant severe asthma will contribute to the identification of optimal therapeutic strategies for the effective management of the disease.]]> Sat 24 Mar 2018 08:23:36 AEDT ]]> The emerging role of microRNAs in regulating immune and inflammatory responses in the lung https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:16016 Sat 24 Mar 2018 08:19:30 AEDT ]]> IL-27/IFN-γ induce MyD88-dependent steroid-resistant airway hyperresponsiveness by inhibiting glucocorticoid signaling in macrophages https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:11518 Sat 24 Mar 2018 08:10:22 AEDT ]]> Alveolar macrophages stimulate enhanced cytokine production by pulmonary CD4⁺ T-lymphocytes in an exacerbation of murine chronic asthma https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:11339 Sat 24 Mar 2018 08:08:17 AEDT ]]> MicroRNA: potential biomarkers and therapeutic targets for allergic asthma? https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:16891 Sat 24 Mar 2018 08:00:49 AEDT ]]> Respiratory viral infection, epithelial cytokines, and innate lymphoid cells in asthma exacerbations https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:20751 Sat 24 Mar 2018 08:00:25 AEDT ]]> The 'classical' ovalbumin challenge model of asthma in mice https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:5604 Sat 24 Mar 2018 07:49:22 AEDT ]]> Steroid-resistant neutrophilic inflammation in a mouse model of an acute exacerbation of asthma https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:5638 Sat 24 Mar 2018 07:44:01 AEDT ]]> Differential injurious effects of ambient and traffic-derived particulate matter on airway epithelial cells https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:27228 Sat 24 Mar 2018 07:32:23 AEDT ]]> Targeting eosinophils in asthma https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:4795 Sat 24 Mar 2018 07:20:43 AEDT ]]> Interferon-γ, pulmonary macrophages and airway responsiveness in asthma https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:22078 Sat 24 Mar 2018 07:15:16 AEDT ]]> Using multiple online databases to help identify microRNAs regulating the airway epithelial cell response to a virus-like stimulus https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:22161 Sat 24 Mar 2018 07:14:59 AEDT ]]> Modeling T<inf>H</inf>2 responses and airway inflammation to understand fundamental mechanisms regulating the pathogenesis of asthma https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:33088 H2 cells), their associated cytokines, and eosinophils in the regulation of hallmark features of allergic asthma. Notably, we consider the complexity of type-2 responses and studies that have explored integrated signaling among classical TH2 cytokines (IL-4, IL-5, and IL-13), which together with CCL11 (eotaxin-1) regulate critical aspects of eosinophil recruitment, allergic inflammation, and airway hyper-responsiveness (AHR). Among our most important findings, we have provided evidence that the initiation of TH2 responses is regulated by airway epithelial cell-derived factors, including TRAIL and MID1, which promote TH2 cell development via STAT6-dependent pathways. Further, we highlight studies demonstrating that microRNAs are key regulators of allergic inflammation and potential targets for anti-inflammatory therapy. On the background of TH2 inflammation, we have demonstrated that innate immune cells (notably, airway macrophages) play essential roles in the generation of steroid-resistant inflammation and AHR secondary to allergen- and pathogen-induced exacerbations. Our work clearly indicates that understanding the diversity and spatiotemporal role of the inflammatory response and its interactions with resident airway cells is critical to advancing knowledge on asthma pathogenesis and the development of new therapeutic approaches.]]> Fri 24 Aug 2018 16:27:29 AEST ]]>